Dominant mutations in GJB2, the gene encoding the human gap junction protein connexin26 (Cx26), cause hearing loss.We investigated whether dominant Cx26 mutants interact directly with Cx30.HeLa cells stably expressing nine dominant Cx26 mutants, six associated with 153 non-syndromic hearing loss (W44C, W44S, R143Q, D179N, R184Q and C202F) and three
The American bullfrog Lithobates catesbeianus is one of the 100 worst alien species in the world.It has been introduced to several European countries.During our field search activities in May 2014 and June 2015, Vacuums a male bullfrog advertisement call was heard at Fiesa Lakes in Slovenia.On September 2015, a male specimen of the American bullfro
BACKGROUND: As an important factor affecting meat quality, intramuscular fat (IMF) content is a topic of worldwide concern.Emerging evidences indicate that microRNAs play important roles in adipocyte differentiation.However, miRNAome has neither been studied during porcine intramuscular preadipocyte differentiation, nor compared with Vacuums subcut
In this paper, a double closed-loop backstepping controller is designed for 3D trajectory tracking of a turtle-inspired amphibious spherical robot suffering from problems that include model uncertainties, environmental disturbances, and unmeasured velocity.The proposed controller scheme tackles three primary challenges: the differentiation explosio
The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a monomer and a pentameric ion channel.Each form has an independent role during replication; the monomer disrupts the secretory pathway, DINING CHAIRS and the pentamer facilitates virion production.T